1.towards or in a lower place or position, especially to or on the ground or another surface.
“she looked down”
synonyms: towards a lower position, downwards, downstairs, towards the bottom, from top to bottom More
2.to or at a lower level of intensity, volume, or activity.
“keep the noise down”

1.from a higher to a lower point of (something).
“up and down the stairs”
synonyms: lower in/on, to the bottom of
“the lift plunged down the shaft”
2.throughout (a period of time).
“astrologers down the ages”
synonyms: throughout, through, during, in
“we have done him many favours down the years”

1.directed or moving towards a lower place or position.
“the down escalator”
2.unhappy; depressed.
“he’s been so down lately”
synonyms: depressed, sad, saddened, unhappy, melancholy, miserable, wretched, sorrowful, gloomy, dejected, downhearted, disheartened, despondent, dispirited, low, in low spirits, low-spirited, heavy-hearted, glum, morose, dismal, downcast, cast down, tearful;

1.knock or bring to the ground.
“175 enemy aircraft had been downed”
synonyms: knock down, knock over, knock to the ground, throw to the ground, bring down, bring to the ground, fell, topple, prostrate, tackle, rugby-tackle, trip up; More
2.consume (something, typically a drink).
“he downed five pints of cider”
synonyms: drink (up/down), gulp (down), guzzle, quaff, drain, imbibe, sup, slurp, suck, sip, swallow, finish off, polish off; More

1.AMERICAN FOOTBALL
a chance for a team to advance the ball, ending when the ball carrier is tackled or the ball becomes out of play. A team must advance at least ten yards in a series of four downs in order to keep possession.
2.informal
unwelcome experiences or events.
“there had been more downs than ups during his years at Ferrari”
synonyms: setbacks, upsets, reverses, reversals, reversals of fortune, downturns, mishaps, strokes of ill luck, strokes of bad luck, accidents, shocks, vicissitudes, crises, catastrophes, tragedies, calamities, trials, crosses, knocks, burdens, blows, buffets